Custom Model Generation

TransViragen is a premier provider of services for the creation of genetically engineered mice and rats.  We use a broad range of the latest technologies, including nuclease-mediated genome engineering, and offer the most complete selection of custom model generation services in the marketplace. With a dedicated commitment to customer satisfaction, TransViragen provides clients with innovative and flexible service offerings to meet their specific requirements, as well as nimbleness to quickly adapt to their changing priorities.  And our comprehensive full-service guarantees are unsurpassed in the industry.  Our clients have come to value the TransViragen advantage for reliable, timely and cost-effective solutions to their research model needs.

Contact us today for a free consultation.  Our expert scientists will take the time to discuss your model requirements and provide you with guidance on specific design options.

The wide variety of model types available from TransViragen include:

Model Types

Constitutive Knockout: complete inactivation of targeted gene in every tissue

Conditional Knockout: inactivation of targeted gene in tissue-specific and/or temporal manner

Knock-In: targeted insertion of genetic element, such as human gene, reporter gene, point mutation or regulatory element, into an endogenous locus

Conditional Knock-in: insertion of genetic element into an endogenous locus in tissue-specific and/or temporal manner

Large Deletions: deletion of large genomic region

Multi-Allele Models: modification of multiple alleles (e.g. knockout or point mutation knock-in) in the same animal

Transgenic: random insertion of transgene construct

BAC Transgenic: random insertion of BAC transgene construct

IKMC Models: mouse models generated using materials (targeting vectors or ES cells) from the International Knockout Mouse Consortium (KOMP / EUCOMM / NorCOMM)

 

Strains

Mouse:   C57BL/6J, C57BL/6N, FVB, Balb/c, NOD, 129
Other custom strains available upon request

Rats:  Sprague Dawley, Wistar, Fischer 344
Other custom strains available upon request